The Top 10 Addictive Substances

I was reading The Fix, my weekly online addiction magazine, and I came across an interesting article on the top ten addictive drugs in order of dependence. 

Many factors determine whether you’ll become addicted to a drug:

ü  Your genetic makeup

ü  Social history

ü  The drugs your friends take

ü  How much money you make

ü  Emotional instability

A team of researchers led by Professor David Nutt of London's Imperial College recently set out to determine which drugs were most harmful based on their addictive properties.  The resulting article suggested that alcohol and tobacco are more harmful than cannabis and ecstasy, and led to Nutt getting sacked as the UK’s top drug adviser.  Dutch scientists replicated the London study and devised a “dependency rating” that measured addictive potency of the biggest drugs out there on a precisely calibrated scale of 0-to-3.

1. Heroin

Dependence Rating: 2.89/3.00


No surprise here: heroin’s addictiveness is the stuff of legend.  As an opiate, it affects opioid receptors throughout the body and mimics endorphins, reducing pain and causing pleasure.  Areas of the brain involved in reward processing and learning are stocked with tons of these opioid receptors, so when you inject heroin, you are basically training your brain to make you crave it.  Pair that with nasty withdrawal symptoms and high fat solubility (which allows it to get into your brain quickly), and you have the most addictive drug in the world.  

2. Crack Cocaine

Dependence Rating: 2.82/3.00


Although crack cocaine and powder cocaine have similar chemical compositions and effects, smoking processed crack causes a faster, higher rush that lasts for less time (about 10 minutes, versus 15-30 for powder cocaine).  The intensity of the high combined with the efficient method of ingestion—smoking—are the big reasons why addiction rates are dramatically higher for crack than they are for snorted powder.  

3. Nicotine

Dependence Rating: 2.82/3.00

Though nicotine doesn’t cause the rush of heroin or crack, it's biologically similar in a crucial way:  it mimics a common neurotransmitter—so well that scientists named one of the acetylcholine receptors after it.  Smoking regularly reduces the number and sensitivity of these “nicotinic” receptors, and requires that the user keep ingesting nicotine just to maintain normal brain function. There are 50,000,000 nicotine addicts in the US, and one in every five deaths nationwide are the result of smoking. 

4. Methadone

Dependence Rating: 2.68/3.00

In a clinical setting, tolerance to this drug is actually considered a good thing when treating a heroin addiction.  A junky getting treated with methadone will quickly become resistant to its euphoric effects and use it to keep heroin withdrawal symptoms at bay.  The problem is this: tolerance to methadone is a sign of an addiction to methadone.

5. Crystal Meth

Dependence Rating: 2.24/3.00

Crystal methamphetamine takes it to the next level:  it imitates the reward chemical dopamine and the alertness chemical norepinephrine, causing your neurons to release more of both—all the while training your brain to want them more.  What’s worse, the drug can damage dopamine- and norepinephrine-releasing neurons, which leads to a drastic decrease in their production, thereby making you crave more meth.  It’s an addict’s nightmare and a marketer’s dream.

6. Alcohol

Dependence Rating: 2.13/3.00

Because alcohol is legal and often consumed in social settings, alcohol addiction is complicated.  But as an addictive agent, it’s remarkably simple—and effective.  Alcohol’s withdrawal syndrome is so severe that it can cause death, and its effects on the brain’s reward system cause well-documented and intense craving in heavy drinkers.  

7. Cocaine

Dependence Rating: 2.13/3.00

Cocaine prevents the reabsorption of dopamine in the brain’s reward areas.  After you use enough blow, your brain reduces the number of dopamine receptors in this region, figuring it's already got plenty of it.  Because there are now fewer receptors, stopping the drug makes you crave it—after all, the body needs its dopamine.  Cocaine doesn’t destroy dopamine neurons like methamphetamine, which makes its effect less powerfully addictive, but the fast method of use (snorting), short high (less than an hour) and rapid tolerance put it in the top ten.

8. Amphetamines (classified as pure or blended dextroamphetamine without methamphetamine)

Dependence Rating: 1.95/3.00

Regular amphetamines including Adderall, Dexedrine, and Desoxyn might not be quite as addictive as meth, but because it acts on the same reward circuit, it still causes rapid tolerance and desire for more if used regularly or in high doses.  Quitting cold turkey can cause severe depression and anxiety, as well as extreme fatigue—and you can guess what extreme fatigue makes you crave...

9. Benzodiazepines (Valium, Xanax, Klonopin, et al)

Dependence Rating: 1.89/3.00

There’s a reason your doctor will tell you to taper off these prescription anti-anxiety drugs after taking them for a while.  Each one increase the effectiveness of a brain chemical called GABA, which reduces the excitability of many other neurons and decreases anxiety. Because benzodiazepines cause rapid tolerance, quitting cold turkey causes a multi-symptom withdrawal that includes irritability, anxiety and panic attacks—enough to make just about anybody fall right back into Benzo's comforting arms.

10. GHB (gamma hydroxybutyrate)

Dependence Rating: 1.71/3.00

Last on the list is a depressant and club drug that may itself be a neurotransmitter. GHB is illegally produced in home basement labs, usually in the form of a liquid that has no odour or colour. It is known as a designer drug because it is specifically made for the purpose of getting people high.  Like Ecstasy, GHB is a popular drug with club-goers and those who go to "rave parties," including teens and young adults.  Its side effects can be very dangerous, especially if the drug is mixed with alcohol.  It has cross-tolerance with alcohol—if you drink regularly, you'll need to ingest more GHB to get high—as well as a short half-life in the body and a brutal withdrawal syndrome that causes insomnia, anxiety, dizziness and vomiting.  The combination is nasty:  Take a lot of GHB to make up for your tolerance to alcohol and you could be hooked.

Do you take any of the above either socially or with a doctor’s prescription?   Are you surprised or worried about the results?  Leave a comment below and let us know!